Middle Colonies
The middle colonies, grossly over-simplifying it, were, and is the best region out of the 3, New England, Southern, and us, the Middle Colonies. The reasons? First off, we had great geography, allowing us to become the Colonies's breadbasket, growing more wheat than anywhere else. Secondly, we had the best relations with natives, letting us trade, and getting more exotic resources, rather than just pillaging and raiding with the natives. Finally, we are the most religion friendly, including Pennsylvania, and New Jersey, which both were founded for religious reasons.
So, what are you waiting for? Why not come to the Middle Colonies today!